Throughout history the known world has been swept by waves of infectious diseases, sometimes from novel sources but sometimes from surges of old enemies. This course will examine common psychological and sociocultural responses as humans faced the approaching menace, reacted to its peak destructive effects, and recovered a new normalcy. Examples are: denial, alarmism, unfounded reassurances, doomsday prophecies, extreme withdrawal, and reckless defiance. Each was expressed in the conceptual frameworks of their times. We will use Bubonic Plague, Smallpox, 1852-60 Cholera Pandemic, 1918 Spanish Flu, HIV/AIDS, and COVID-19 to illustrate.